Outbound SMTP e-mail is blocked by Virus Scan Enterprise (VSE) 8.x Access Protection rule on Port 25
Blocked items include:
Alert and event notifications from McAfee products such as Vulnerability Manager and Network Security Platform
Mail from third-party email applications.The VSE 8.x Access Protection feature allows the user to block specific ports. Although standard exclusions are set, SMTP error from the vRanger e-mail feature must manually revise and excluded.