If you are not able to connect to newly created SQL DB from newly installed GPOADmin 5.21 instance.(If you use custom port than also its not accessible)
When tested with NT authentication and account having full access to DB and also with local SQL acct and both fail with same error, cannot connect to SQL.
When tested connection to the DB via UDL test and If you use the SQL server FQDN if connects successfully but if you use SQL servername\instacename, UDL test will fail to connects.
In GPOADmin 5.21 and we did find an issue not in how we set the encryption for the database server, rather in where we check that the SQL server is a valid server. The method we are using that was introduced in GPOADmin 5.21 will check in AD that the machine entered into the SQL server dialog box is present in AD. If it is not the connection will fail marked as the server does not exist.
This is why when you uses the FQDN to connect that it fails. The FQDN is present as a CNAME record in DNS, however it does not have a corresponding computer object in AD and fails the existence check.
We have created a defect to address this in a future version of GPOADmin. The defect ID is 587444.
For now use the GPOADMin 5.20 version as a workaround for this issue.
Since the UDL test was successful using the SQL Server FQDN, please use the same connection method to complete the GPOADmin Configuration Wizard setup for version 5.20. Create the DB manually using scripts comes with the GPOADMin 5.20 and connect that DB to GPOADmin 5.20.