When attempting to configure the a Virtual Appliance to a VMware cluster the option is not available.
May not be supported by your version of vRanger.
Be sure you are running vRanger 5.4.0.25201 or higher (Help>About vRanger Backup & Replication).
Also, the Virtual Appliance needs to be version 1.5.0 as displayed in vSphere on the Summary tab under General.