In the View | Toad Options | File | General | Edit window, once a file type is associated to be opened with Toad, the association type of this file type cannot be changed back to it's original state.
Steps that leads to issue:
1. Select View | Toad Options
2. Select File | General
3. Click Edit and check the box Open with Toad
4. Hit OK, click on Edit again for the same file type and the check box is disabled
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