Error: "Cannot perform this operation on a closed dataset" after trying to read grid information (4225863)

I have a long running query that I start the night/day before and work with it during the day and the next. If I let it run, and work with the grid and data soon after it returns, there are no problems; but if I run it and let it sit idle (for instance over night and come back the next day to work with the grid and data) it can give me the error "Cannot perform this operation on a closed dataset".

If I click reconnect in the Session menu, the grid refreshs the information is lost and the datagrid cleared.