Yes, MNE 4.15.1.219 and later support Outlook 2016 for both the MNE migration server and for the Self-Service Desktop Migrator (SSDM) utility.
Default mail client must be a 32-bit edition (only) of Outlook 2013 or Outlook 2016 with the latest updates applied.
A link to the latest MNE hotfix can be found in the the following KB article:
What is the latest hotfix for Migrator for Notes to Exchange?
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