ERROR: [7456-6-43-80020009] Unable to initialize GroupWise Connect (GWSYSTEM\GWISE\GRPWISE\ ):
 Exception occurred.
This is most commonly an issue with permissions to the Groupwise domain files.
Open ConsoleOne and try to connect to the domain database at the domain path I.E: \\GWSYSTEM\GWISE\GRPWISE\ and verify it is reachable without an authentication request
As a test to exclude any access problems, copy the folder I.E: \\GWSYSTEM\GWISE\GRPWISE\ to a local destination on the migration console and try pointing GroupWise Migrator to it. If the error is not shown anymore, then there is still a permissions / access problem at some point.
Verify that the Novell User which is logged on the migration console has full read/write over the domain path and can navigate to it using windows explorer.
As per the Novell website (https://www.novell.com/documentation/nwec/pdfdoc/nwec/nwec.pdf), Error 7 is an OVERWRITE_ERROR.
Please try to remove and recreate the Trusted App key as per this article: Solution 18265