When a client is configured to use a left handed mouse the settings are not being passed to the vWorkspace session.
1) Install the full manufacturer's mouse driver (not the Microsoft Windows HID driver) on the local machine.
2) the user must manually change the settings in the remote session to be left handed,
3) vWorkspace or other Profile management software can be enabled to capture the HKCU/Control Panel/Mouse/ SwapMouseButtons setting and apply it each time the user makes a connection
The enhancement has been submitted to the vWorkspace development team for consideration in a future version of vWorkspace