To confirm that the process completed as expected, please view Settings | Logs and change the drop-down to Updates. The logs should state that the security hotfix was applied. You can also verify by going to the "Exim Main Log" and notice messages that mention "removed by root" after running the hotfix.
As a best practices approach, make sure that on Settings > Control Panel > Network Settings, at the bottom, uncheck the "Enable SMTP Local Server (Inbound)" if this feature is not used, which is to be able to receive email via Exchange Servers. Also if the "Enable SMTP Remote Server (Outbound Relay)" is enabled, make sure that credentials are in place, anonymous connections tend to cause loop/bounce-back issues.
If the issue continues after applying the hotfix, please contact support here.
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