1. Ensure .NET 4.0 (or higher) is installed on the the server running Quest Knowledge Portal.
2. Reinstall ASP.NET (4.0), for example:
%windir%\Microsoft.NET\Framework64\v4.0.30319\aspnet_regiis.exe -i
3. Ensure ASP.NET (4.0) ISAPI and CGI extensions are allowed.
a. Via IIS Manager click on the server name in the left pane
b. Double-click ISAPI and CGI Restrictions.
c. Ensure both ASP.NET v4.0.30319 entries are listed and set to Allowed under the Restrictions column.
4. Revert handler mappings to parent.
a. Go to IIS and highlight the QuestKnowledgePortal site.
b. Double-click on the Handler Mappings icon
c. Click on Revert to Parent on the on the Actions pane (right-hand side)
5. Try to load the Knowledge Portal website again.
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