EMWProf log file contains this entry:
11/21/2006 1:59:20 PM SM [Warning] Cannot open the message store 'XXX XXX'.
Standard error.
Error code: 0x00000003
Description: The system cannot find the path specified.
This error indicates that the mailbox has an associated PST file, but at the moment of processing, the PST file is not available (accessible).
To eliminate the error and resolve the problem either remove the PST files from users mailbox or make them available by eg. placing them locally or on a mapped network drive.
The following KB article SOL22161 might be interesting when using mapped drives:
Solution SOL22161 - EMWPROF fails with "[Error] Cannot open default message store. MAPI error. Error code: 0x80040113" -https://support.quest.com/SUPPORT/index?page=solution&id=SOL22161
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