Can I run a Content and Attachments Gathering against my entire organization?
It is not recommended to create a Content and Attachment gathering for over 10 mailboxes at a time.
The Content and Attachment gatherings are designed to capture detailed point in time information on a mailbox or a few mailboxes that are under investigation, rather than gathering statistical data. Each time the the gathering runs it must completely regather the content of each mailbox. It is highly recommended to run this gathering against small groups of mailboxes at one time as it creates a large amount of overhead on the MessageStats server.
For More information please see the section titled "Gathering Content and Attachment Informaiton" in the MessageStats Administators Guide.