In some large environments where we don't want to manage all domains from GPOAdmin we might need to exclude the unnecessary domains to avoid delays and performance issues.
To exclude one or several domains you can do it from the GPOAdmin console or via registry key.
Method 1 Via Console
Right-click on the Live environment and select properties
Then click on the Domains tab and uncheck any domains you do not want to audit.

Method 2 Via reg key
Open the registry editor and go to:
HKLM > SOFTWARE > Quest > GPOADmin > VCConfig
Create a new Multi-string value and name it ExcludedDomains enter all the domains to exclude one per line
Each domain to be excluded should be a separate string entry in that value with it's FQDN.
