CAUSE 1
Many agents (DB, infrastructure, VM) are configured (100's). The 'Short term' policy template was selected under Dashboards | Management Server | Servers | Data Management; Retention Policy > "Current policy:".
"Short term" causes MORE data to be kept for a short period of time, and if many agent are configured, this will cause a the repository topology size to increase in a short amout of time.
CAUSE 2
All or many of the DB agents have CUSTOM retention policies defined under "Agent Settings | Administration | Retention Policies
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Note: Retention policies determine how long data collections are kept. A longer retention policy increases data granularity, but also increases resource consumption.
RESOLUTION 1