When removing the snapshot of the virtual machine residing on the NFS storage in an ESX/ESXi 4.1 host, you may experience these symptoms:
This issue may occur if you are using a backup application that utilizes Changed Block Tracking (CBT) and the ctkEnabled option for the virtual machine is set to true. The virtual machine becomes unresponsive for up to 30 seconds as NFS locks on the .ctk file are changed.
This issue is resolved in ESX 4.1 patch ESX410-201104401-SG and ESXi 4.1 patch ESXi410-201104402-BG.