Yes, the only thing Desktop Authority does when replicating is it signs the files with a unique signature from the DA manager console and then copies them to the target server and share specified in the DA manager console. The DA replication process (or copy) can be made to a target running FRS, DFSR or neither. Once the files have been signed and copied to any target, they may be copied elsewhere, by any method, and the signature will remain intact.
Desktop Authority performs automatically actions that can be done manually. If the client supports the action then Desktop Authority will do it as well. As most Windows clients support DFS namespaces, then Desktop Authority will be able to use that configuration in its elements paths and validation logic rules, using the format \\Domain\DFS-Namespace\Share\ instead of the UNC: \\Server\Share format.
For more information please refer to Microsoft Technet KB Article ID: 782417 – “How DFS Works”