Notification Emails Fail with Error: 554 5.2.0 "SendAsDeniedException" (4293987)

After upgrading from an older version of the KACE Systems Management Appliance (SMA) or after changing mail settings, it may be noted that notification emails from the Service Desk cease. Upon reviewing logs, it is noted that the following error exists:

SMTP<< 554 5.2.0 STOREDRV.Submission.Exception:SendAsDeniedException.MapiExceptionSendAsDenied; Failed to process message due to a permanent exception with message Cannot submit message.

Note: Please note that while there are many different mail errors and possible points of failure, this article is about one specific situation. For assistance with mail troubleshooting, please see the Email Configuration Report and Contact Technical Support with any questions or concerns.