Please go to Utilities | Automation Designer and create a new application.
On the DB Misc tab select the Compare schemas action and fill it with the desired options.
You can run this app everytime you want to generate a compare schema and the selected settings will be there.
After doing this, if you go into Toad's main menu to do your schema compares, Toad will look through the "Action Recall" section of the Automation Designer for any schema compares that you have done from your current connection. If it finds one, it will load those settings (that is, settings from the last schema compare for the current connection). If it doesn't, it will revert to default values.