There may be a security requirement that internal websites, such as the Quest Knowledge Portal (QKP), have the .Net Trust Level set to "Medium" rather than the default "Full".
The .Net Trust Level is set for a website using the following method:
- Open the IIS Manager
- Click the site name under review
- Double-click the .NET Trust Level icon
- Set the desired .Net Trust Level
However, setting the .Net Trust Level for the QKP website set to "Medium" rather than the default "Full" with cause the QKP website to fail with the error: "Required permissions cannot be acquired."