DR4100 is presenting broken pipe errors when receiving replicating vRanger savepoints.
Events in Target DR4100 displays disconnections. The Schedules configuration window is taking an abnormal amount of time to load and then it fails.
MTU size change to 9000 on DR's (Local and Remote) to improve Backups and Restore times, but this affects replication of CIFS and RDS replication using vRanger over WAN networks.
Both type of replications and Schedule UI stopped working.
If network between DR's doesn't support large MTU sizes, MTU must be set back to default size of 1500.
This can be done in the WebUI > System Configuration > Networking.