The 'What's New' document for 4.6 indicates that Exchange 2010 rollup 5 is supported but the Release Notes for 4.6 indicate that rollup 6 is supported.
The 'What's New' document is incorrect therefore Change Request # 103561 has been created to address this discrepancy.
Exchange 2010 rollup 6 is supported in Archive Manager 4.6 as per the Release Notes