"The underlying connection was closed: An unexpected error occurred on a send. The handshake failed due to an unexpected packet format."
1. Remove the replication relationship to remove the old registry replication settings. Afterwards, configure replication again which will apply the correct registry settings.
2. If there was a change in ISP you will need to be aware of any new gateway firewalls that may now affect the environment and AppAssure. Exceptions for IP addresses and ports may need to be applied.